Nuestros auspiciadores

ATENCIÓN. Muchos de los artículos (o sus resúmenes) que aparecen en este listado bibliográfico pueden obtenerse a través de la Biblioteca Nacional de Medicina de los Estados Unidos (Medline), realizando una búsqueda con el término Alpha-1 Antitrypsin Deficiency.  Algunos ya tienen un enlace. Sólo tienes que pinchar con el ratón sobre la referencia.

PARA LEER LOS ARCHIVOS EN FORMATO  NECESITA EL PROGRAMA ACROBAT READER QUE SE OBTIENE GRATIS EN:

Terapia de Reemplazo Endovenosa: Comprensión Actual, Stoller, L S Aboussouan, THORAX  2004 59:708-712	ESPAÑOL	PORTUGUES
Epidemiología de la Deficiencia de Alfa-1 Antitripsina, M Luisetti, N Seersholm, THORAX 2004; 59: 164-169	ESPAÑOL	PORTUGUES
Fisiopatología Molecular, DA Lomas,  H Parfrey, THORAX 2004; 59: 529-53	ESPAÑOL	PORTUGUES
Manifestaciones Clínicas e Historia Natural, M. Needham, R. A. Stockley, THORAX 2004; 59:441-445	ESPAÑOL	PORTUGUES
Tratamientos Nuevos y Emergentes para la Deficiencia de Alfa-1 Antitripsina, THORAX 2004; 59: 904-909	ESPAÑOL	PORTUGUES
Expresiones Clínicas de la Deficiencia Alfa-1 Antitripsina (DA1A), Pisonero-Ruiz, P, et. al. , HEPATOLOGÍA CLÍNICA, Núm. 4 Vol. 7, 1999, pp 163-170	ESPAÑOL	PORTUGUES
Deficiencia de Alfa-1 Antitripsina, Iujvidin S, Alfonzo E, 2005	ESPAÑOL	PORTUGUES
Enfisema por déficit de alfa-1-antitripsina: ¿es realmente una enfermedad infrecuente?, MED CLIN (Barc) 2004; 123(20):778-9	ESPAÑOL	PORTUGUES
Deficiencia de Alfa-1 Antitripsina en Puerto Rico, Lebrón F., PRENSA MEDICA Año 16, Núm 1, 11-13	ESPAÑOL	PORTUGUES

PORTUGUES

Alfa-1-antitripsina – a luta pela vida, Rey AS, Barbosa KBB, Oliveira MVC et al ,Pulmão RJ 2006;15(2):133-134

ESPAÑOL E INGLES

Proyecto IDDEA (Información y Detección del Déficit de Alfa-1-antitripsina)

Osteoporosis en la Enfermedad Pulmonar Obstructiva Crónica, Saab MA, et.al., Revista Argentina de Medicina Respiratoria, Año 4 Nº 1 : 38-47

"Análisis de nuestros resultados en cirugía de reducción de volumen pulmonar en enfisema", Gafas, Pablo et.al, Revista Patología Respiratoria, 2002; 5(4):141-7.

"Cambio en la función pulmonar y morbilidad de los afectados de enfermedad pulmonar obstructiva crónica entre heterozigotosos MZ para la alfa-1 antitripsina--un estudio longitudinal de la población", Dahl, Morten, y otros, Annal Of Internal Medicine, 19 de febrero de 2002, Vol. 136, nº4, pp. 270-279.

 "Determinación de actividad elastasa y tripsina en niños asmáticos", Albuerne, Yeani, et.al., REV CUBANA INVEST BIOMED, 2000;19(3):16B-71."Déficit de Alfa-1 Antitripsina. Presentación de 25 casos. Pons S, et. al., Bol Soc Val 2000;20.

"Una Deficiencia Poco Conocida", Pisonero-Ruiz, P., M.D., Alfonzo-Cabiya, EL NUEVO DIA, Suplemento SALUD AL DIA, 31 de marzo del 2000.

"Deficiencia de Alfa 1-Antitripsina:  Estado Actual", Pisonero-Ruiz, P., et. al.,  ACADEMIA DE MÉDICOS DE FAMILIA, junio 1999, Año 10, Núm. 6, pp 20-26.

"El Déficit de Alfa-1 Antitripsina y el Enfisema Pulmonar", Pisonero-Ruiz, P., et.al., MÉDICO INTERAMERICANO, 1999, Vol. 18, No. 7, pp 336-338.

"Deficiencia de Alfa-1 Antitripsina", Ríos-Mollineda, R, PRENSA MÉDICA, abril 1996, Año 8, Núm. 2, pp 23-24.

"Informe del Registro Español de Pacientes con Déficit de Alfa-1 Antitripsina", Vidal R, Miravitlles M y Grupo de Estudio del Déficit de Alfa -1 -antitripsina ,  ARCH BRONCONEUMOL 1995: 31: 299-302.

ESTUDIO LONGITUDINAL--CRIBADO (SCREENING) NEONATAL

"¿Cuál es el futuro del cribado (screening) neonatal para la Deficiencia de Alfa-1 Antitripsina?", Sveger T, Thelin T, ACTA PAEDIATR, 2000 Mar;89(3):259-61

" Niños de cuatro años de edad con Deficiencia de Alfa-1 Antitripsina--Seguimiento clínico y actitudes de los padres hacia el cribado (screening) neonatal", Sveger T, Thelin T., ACTA PAEDIATR SCAND, 1981 Mar;70(2):171-7.

"Enfermedad del hígado ocasionada por la Deficiencia de Alfa-1 Antitripsina detectada a través de un cribado (screening) neonatal de 200,000 infantes", Sveger T., N ENGL J MED, 1976, Jun 10;294(24):1316-21,

" El hígado en adolescentes con Deficiencia de Alfa-1 Antitripsina", Sveger T, Eriksson S, HEPATOLOGY, 1995 Aug;22(2):514-7.

ARTICULOS TERAPIA DE REEMPLAZO AAT

Intravenous augmentation therapy: current understanding, J K Stoller, L S Aboussouan, Thorax 2004;59:708–712.

Terapia de reemplazo AAT, Laboratorios Grifols, Barcelona, España--estudios clínicos

"Efecto de la Terapia de Reemplazo sobre la Inflamación Bronquial en la Deficiencia de Alfa-1. Robert A. Stockley, Darren L. Bayley, Ipek Unsal and Lee J. Dowson, American Journal of Respiratory and Critical Care Medicine Vol 165. pp. 1494-1498, (2002) (Resumen)

The Effect of Augmentation Therapy on Bronchial Inflammation in 1-Antitrypsin Deficiency, Stockley, R., AM J RESPIR CRIT CARE MED, 2002, Vol 165, 1494–1498.

"Seguimiento longitudinal de los pacientes con Déficit de Alfa-1 Antitripsina antes y durante el tratamiento sustitutivo intravenoso", Wencker, MD, et. al., CHEST 2001; 119; 737-744.

Prolastin®:  Realidad o Fantasía--Prueba versus efecto placebo", James Stocks, M.D., ALPHA-1 NEWS, Vol. 11, Núm. 3, junio 2000. (Traducción del inglés)

"La terapia de reemplazo reduce la frecuencia de las infecciones pulmonares en la Deficiencia de Alfa-1 Antitripsina--Una hipótesis con data que la sustenta" (Augmentation Therapy Reduces Frequency of Lung Infections in Antitrypsin Deficiency--A New Hypothesis With Supporting Data, " Lieberman J, CHEST 2000; 118:1480-1485. (Resumen en español)

Augmentation Therapy Reduces Frequency of Lung Infections in Antitrypsin Deficiency--A New Hypothesis With Supporting Data, Lieberman, J, CHEST 2000; 118:1480–1485

Estado actual del tratamiento sustitutivo en el enfisema congénito por déficit de alfa-1 antitripsina. Informe del registro nacional. Miravitlles M, Vidal R, Barros-Tizón JC, Bustamante A, España PP, Casas F, Martínez MT, Escudero C, Jardí R. Arch Bronconeumol 1999; 35: 446-454. (Enlace externo)

¿Debemos administrar tratamiento sustitutivo a los pacientes con déficit de alfa-1 antitripsina?" (editorial). Miravitlles M. Arch Bronconeumol 1998; 34: 109-111. (Enlace externo)

¿Disminuye la Terapia de Reemplazo con AAT la Declinación Anual en la FEV1 en Pacientes con Deficiencia Severa de Alfa-1 Antitripsina?  Seershom, N., et.al., EUR RES J 1997; 10:220-2263.

Randomized Clinical Trial of 1-Antitrypsin Augmentation Therapy. Dirksen A, et.al. A Am. J. Respir. Crit. Care Med., 1999; 160: 1468-1472.

Long-term treatment of alpha-1 antitrypsin deficiency related pulmonary emphysema with human alpha-1 antitrypsin, Wencker M., et.al, EUR RESP J, 1998; 11:428-433.

Does alpha-1 antitrypsin therapy slow down annual decline in FEV1 in patients with severe hereditary alpha-1 antitrypsin deficiency?, Seersholm et.al, EUR RESPIR J, 1997; 10:2260-2263.

PANICULITIS

Alpha-1-antitrypsin deficiency associated with panniculitis treated with plasma exchange therapy, de Oliveira, P., Paz-Melgar, L., Takahashi, M. D. F., Nico, M. M. S., Rivitti, E. A., Mendrone, A., Tatsui, N. H, Vol. 43, Issue 9, Sept., 2004, PP 693-697 (Journal not stated).

Autobodies to neutrophilic proteases in a case of panniculitis by deficit of a1 antitrypsin deficiency, G. Filacy, et.al., RHEUMATOLOGY,2000; 39:128-1290

"Alpha-1 Antitrypsin Deficiency and Panniculitis", Pittelkow, M., et al., AMERICAN J OF MEDICINE, junio 1988; Vol. 84 (suppl 6A) pp 30-36.

"Alpha-1 Antitrypsin Deficiency Panniculitis:  A Histopathologic and Immunopathologic Study of Four Cases", Su, WP, et.al, 1987, AM J DERMATOPATHOL, 9:483.490.

"Protease-Inhibitor Deficiencies in a Patient with Weber-Christian Panniculitis", Bleumink, E y Klokke, HA, 1984, ARCH DERMATOL, 120:936-940.

OTROS ARTÍCULOS

Alpha-1-Antitrypsin Deficiency: Diagnosis, Pathophysiology,and Management, Teckman, J, et.al., CURRENT GASTROENTEROLOGY REPORTS 2006, 8:14–20

Antibody Response to Aerosolized Transgenic Human Alpha1-Antitrypsin, `Spencer, Terry, et.al., N ENGL J MED 352;19 may 12, 2005, 2031-2031

Results of a case-detection programme for a1-antitrypsin deficiency in COPD patients de la Rosa, et.al., EUR RESPIR J  2005; 26: 616–622Soporte Nutricional en el Paciente Neumópata, Fuchs, et.al., Neumología y Cirugía de Tórax, Vol. 64(1), 2005: 5-8."What We Owe to Alpha-1 Antitrypsin and to Carl-Bertil Laurell, COPD, Vol. 1, No. 1, pp 71-84, 2004.

Delay in Diagnosis of Alpha-1 Antitrypsin Deficiency: A Contining Problem, Stoller JK, et.al., CHEST, 128/4/Oct. 2005, 1969-1994.

Trends in the Diagnosis of Symptomatic Patients with Alpha-1 Antitrypsin Deficiency Between 1968 and 2003, Campos, MA, et.al, CHEST, 185/3/Sept 2005, 1179-1185.

 Mortality of Individuals with Severe AAT Deficiency, Stoller J, et.al., CHEST 2005: 127/4, 1196-1204.

Alpha-1-antitrypsin deficiency: diagnosis and treatment, Perlmutter, CLIN LIVER DIS 8 (2004); 839-859.

Long-term results after lung volume reduction surgery in patients with 1-antitrypsin deficiency, Michaela Tutic, MDa, Konrad E. Bloch, MDb, Didier Lardinois, MDa, Thomas Brack, MDb, Erich W. Russi, MDb, Walter Weder, MD, J Thorac Cardiovasc Surg 2004;128:408-413

"Standards for the Diagnosis and Management of Individuals with Alpha-1 Antitrypsin Deficiency", Sociedad Torácica Americana y Sociedad Respiratoria Europea, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol. 168, Núm. 7, Octubre 1, 2003Oct. 2003. (Documento completo) (Resumen Ejecutivo)

Predictors of Mortality in AAT Deficiency, Dawkins PA, et.al, THORAX 2003; 58: 1020-1026.

Standards for the Diagnosis and Managament of Individuals with Alpha-1 Antitrypsin Deficiency, AMERICAN JOURNAL OF RESPIRATORY THERAPY, Vol. 168, Núm. 7, Octubre 1, 2003.

"Genetic epidemiology of alpha-1 antitrypsin deficiency southern Europe: France, Italy, Portugal, and Spain", CLIN GENET, Vol. 63, 2003, Págs. 4990-509.

Alpha-1 Antitrypsin Deficiency Is Not a Rare Disease but a Disease That Is Rarely Diagnosed, deSerres F., EN HEALTH PER, Vol. 111, NUMBER 16, December 2003

Does the Heterozygous State of Alfa-1 Antitrypsin Deficiency Have a Role in Chronic Liver Diseases? Interim Results of a Large Case-Control Study. A. Regev, C. oct. 2003.

A1-antitrypsin PI phenotypes S and Z in Europe: an analysis of the published surveys.Blanco I, Bustillo EF, Rodríguez MC.  (In press)

Distribution of a1-antitrypsin PI S and PI Z frequencies in countries outside Europe: a meta-analysis. Blanco I, Bustillo EF, Rodríguez MC.  Clin Genet 2001; 60: 000-000 (In press). Received 31 July 2001; revised and accepted for publication 26 September 2001

Alpha-1 gene, National Insititutes of Health

Progression of Atherosclerosis Is Associated With Variation in the Alpha-1 Antitrypsin Gene, Talmud et al., Arterioscler Thromb Vasc Biol., 2003; 23: 644-649.

Asthma Features in Severe Alpha-1 Antitrypsin Deficiency--Experience of the National Heart, Lung, and Blood Institute Registry, Eden E., et.al, CHEST, 123/3/March 2003.

Airway hyperresponsiveness in a large group of subjects with alpha-1 Antitrypsin deficiency:  a cross-sectional controlled study, Makerba M., et.al, JOURNAL OF INTERNAL MEDICINE 2003, 253: 351-358.

"A Longitudinal Study of Alpha-1 Antitrypsin Phenotypes and Decline in FEV1 in a Community Population", Silva G., et.al., CHEST 2003, Vol. 123, Págs. 1435-1440.

"Worldwide Racial and Ethnic Distribution of Alpha-1 Atitrypsin Deficiency", de Serres, F., CHEST, Vol. 122, Págs. 1818-1829, Nov. 2002

"Alpha-1 antitrypsin polymerization and the serpinopathies: pathobiology and prospects for therapy", Lomas, DA and Malhadeva R., J CLIN INVEST, Dic., 2002, Vol. 110, Núm. 11, Págs. 1585-1590.

"Liver inury in alpha-1 antitrypsin deficiency: aggregated protein induces mitochondrial injury", Perlmutter, DH, J CLIN INVEST, Dic. 2002, Vol. 110, Núm. 11, Págs. 1579-1583.

"Change in Lung Function and Morbidity from Chronic Obstructive Pulmonary Disease in Alpha-1 Antitrypsin MZ Heterozigotes: A Longitudinal Study of the General Population", Dahl, Morten, et.al., ANNALS OF INTERNAL MEDICINE, 19 Feb. 2002, Vol. 136. No. 4, pp. 270-279.

"Alpha-1 antitrypsin deficiency--pieces of the puzzle", Sandhaus RA, CHEST, Vol. 119, p. 676-677.

"Alpha-1 antytripsin deficiency", Primhak, RA  and Tanner, MS, ARCH DIS CHILD, 2001, 58:2-5.

"Rare alpha-1 antitrypsin phenotypes and liver-test abnormalities during infancy", Pittschieler, K, ACTA PAEDATR 90:406-8, 2001.

"Update on panniculitis", RG Phelps, et.al., THE MOUNT SINAI JOURNAL OF MEDICINE, Vol. 68, Nos. 4 & 5, Sept./Oct. 2001.

"Liver injury in alpha-1 antitrypsin deficiency", Perlmutter, DH, Clinics in liver disease, Vol. 4, No. 3, May 2000

"Risk of Hospital Admission of Obstructive Pulmonary Disease in Alpha-1 Antitrypsin Heterozygotes of Phenotype PiMZ", Seersholm, N., et. al., AM J RESPIR CRIT CARE MED, Vol. 161, No. 1, Jan. 2000, 81-84.

Diagnosis of alpha-1-antitrypsin deficiency by DNA analysis of children with liver disease, De Tommaso AM, et. al., Arq Gastroenterol 2001 Jan-Mar;38(1):63-8

"Enhancing physical performance in crhonic obstructive pulmonary disease", Steiner, MC, Morgan, MDL,THORAX 2001; 56:73-77.

Leukocyte adhesion and recruitment, and alpha-1-antitrypsin deficiency: a report from ATS 2001, May 18-23, San Francisco, Ian Woolhouse Respir Res.  2001; 2(5): E004

Chemical chaperones mediate increased secretion of mutant a1-antitrypsin (a1-AT) Z: A potential pharmacological strategy for prevention of liver injury and emphysema in a1-AT deficiency, Jon A. J. Burrows, Lauren K. Willis, and David H. Perlmutter, Proc. Natl. Acad. Sci. USA. 2000 February 15; 97(4): 1796-1801

"Alpha 1 Antitrypsin Deficiency Associated Liver Disease Progresses Slowly in Some Children", Volper D., et.al., J Pediatr Gastroenterol Nutr. 2000 Sep;31(3):258-63.

"Alpha-1-antitrypsin deficiency: what next?", R A Stockley, THORAX 2001; 55:614-618 (July).

"Alpha-1 Antitrypsin Deficiency:  Epidemiology and Prevalence", Miravitlles, M, RESPIRATORY MEDICINE (2000), 94 (Supplement C), S12-S15.

"Augmentation Therapy Reduces Frequency of Lung Infections in Alpha-1 Antitrypsin Deficiency--A New Hypothesis With Supporting Data", Lieberman, J, CHEST 2000; 118:1480-1485.

"Acute Cigarette Smoke-Induced Connective Tissue Breakdown Is Mediated by Neutrophils and Prevented by Alpha-1 Antitrypsin, Dhami", Rajwinder, et.al., Am. J. Respir. Cell Mol. Biol., Volume 22, Number 2, February, 2000 244-252.

"Glucosidase and Mannosidase Inhibitors Mediate Increased Secretion of Mutant Alpha-1 Antitrypsin", Marcus, N. Y., Perlmutter, D. H. (2000).  Z. J. Biol. Chem. 275: 1987-1992.

"Chemical chaperones mediate increased secretion of mutant alpha-1 antitrypsin (alpha 1-AT) Z: A potential pharmacological strategy for prevention of liver injury and emphysema in alpha 1-AT deficiency", Burrows, J. A. J., Willis, L. K., Perlmutter, D. H. (2000),  Proc. Natl. Acad. Sci. U. S. A. 97: 1796-1801.

"Heteropolymerization of S, I, Z alpha-1 antitrypsin and liver cirrhosis", Mahadeva, R, et. al., J CLIN INVEST 103:999-1006 (1999)

"A kinetic mechanism for the polymerization of Alpha-1 Antitrypsin", Dafforn, TR, et. al., THE JOURNAL OF BIOLOGICAL CHEMISTRY, Vol. 274, No. 14, pp 9548-9555 (1999)

Randomized Clinical Trial of Alpha-1 Antitrypsin Augmentation Therapy. Dirksen A, Dijkman JH, Madsen F, Stoel B, Hutchison DCS, Ulrik CS, Skovgaard LT, Kok-Jensen A, Rudolphus A, Seersholm N, Vrooman HA, Reiber JHC, Hansen NC, Heckscher T, Viskum K, Stolk J. A.  Am. J. Respir. Crit. Care Med., 1999; 160: 1468-1472.

"Quantum Proteolysis by Neutrophils:  Implications for Pulmonary Emphysema in Alpha-1 Antitrypsin Deficiency", Campbell, E., J CLIN INVEST, August 1999, Volume 104, Number 3, pp 337-344.

"Identification of DNA polymorphisms associated with the V type of alpha-1 antitrypsin gene", Gaillard M., et. al., Biochmica et Biophysica Acta 1444 (1999) 16-170.

Alpha-1-Antitrypsin Deficiency Registry Study Group. Survival and FEV1 decline in individuals with severe deficiency of alpha-1-antitrypsin. Am J Respir Crit Care Med 1998;158:49-59.

"Long-term Treatment of Alpha-1 Antitrypsin Deficiency-Related Pulmonary Emphysema With Human Alpha-1 Antitrypsin", Wencker, M, et.al., Eur Respir J 1998; 11:428-433.

"Usefulness of  a National Registry of Alpha-1 Antitrypsin Deficiency: The Spanish Experience", Miravitlles M, Vidal R, Barros-Tizón JC, Bustamante A, España PP, Casas F, Martínez MT, Escudero C, Jardí R, RESPIR MED, 1998; 92: 1181-1187.

"Alpha-1 Antitrypsin Deficiency: From Genotype to Childhood Disease", Marcus, N., Teckman J., Perlmutter, D., J OF PED GASTROENTEROLOGY AND NUTRITION, July 1998, Vol. 27, No. 1, pp 65-74.

"Late Onset Genetic Disease:   Where Ignorance is Bliss, Is It Folly to Inform Relatives", Wilcke Jon T., BMJ, Sept. 1998, Vol 317, pp 744-747.

"Alpha-1 Antitrypsin Deficiency", Perlmutter, D., SEMINARS IN LIVER DISEASE, 1998, Vol. 18, No. 3, pp 217-225.

"Increased Risk of Chronic Liver Failure in Adults With Heterozigous Alpha-1 Antitrypsin Deficiency", Graziadel I., et. al., HEPATOLOGY, 1998, Vol. 28, No., pp 1058-1063. (Resumen)

"Does Alpha-1 Antitrypsin Augmentation Therapy Slow the Annual Decline in FEV1 in Patients With Severe Hereditary Emphysema?", Seershom, N., et.al., EUR RES J 1997; 10:220-2263.

"Clinical Features and Natural History of Severe Alpha-1 Antitrypsin Deficiency", Stoller, James, K., CHEST, 1997, 111:123S-128S.

"Alpha-1 Antitrypsin (AAT) Deficiency and ANCA-Positive Systemic Vasculities:  Genetic and Clinical Implications", Callea, F., et.al., EUR J CLIN INVEST, 1997, 27:696-702.

"Clinical Fetures and Prognosis of Life Time Non-Smokers with Severa Alpha-1 Antitrypsin Deficiency", Seersholm, N., Kok-Jensen A., BMJ, Dec. 1997, pp.

"Alpha-1 Antitrypsin Deficiency Report of the WHO Meeting", Human Genetics Programm, Division of Noncommunicable Diseases, Geneva, Italy, March 1996.

"A 30-Year Perspective on Alpha-1 Antitrypsin Deficiency", Eriksson, S., CHEST SUPPLEMENT, Dec., 1996, Vol. 110, No. 6, 237S-241S.

"Alpha-1 Antitrypsin Deficiency:   A Conformational Disease", Carrell, R., et. al.,  CHEST SUPPLEMENT, Dec., 1996, Vol. 110, No. 6, 243S-247S.

"Pathogenesis of Hereditary Emphysema and Replacement Therapy for Alpha-1 Antitrypsin Deficiency:  Insight Into the More Common Forms of Emphysema", Gadek, J.,  CHEST SUPPLEMENT, Dec., 1996, Vol. 110, No. 6, 248S-250S.

"Pathogenesis and Pathology of Liver Disease Associated with Alpha-1 Antitrypsin Deficiency", Massi, G.,  CHEST SUPPLEMENT, Dec., 1996, Vol. 110, No. 6, 251S-255S.

"Use of Secretory Leukoiprotease Inhibitor to Augment Lung Antineutrophil Elastase Activity", Buhl, R., et. al.,   CHEST SUPPLEMENT, Dec., 1996, Vol. 110, No. 6, pp 267S-272S.

"Bioengineering:  Alpha-1 Proteinase Inhibitor Site-Specific Mutagenesis:  The Prospect for Improving the Inhibitor", Luisetti, M., et. al.,  CHEST SUPPLEMENT, Dec., 1996, Vol. 110, No. 6, 278S-283S.

"Lung Transplantation for Alpha-1 Antitrypsin Deficiency", Trulock, E.,  CHEST SUPPLEMENT, Dec., 1996, Vol. 110, No. 6, 00 284S-294S.

"Systemic Necrotizing Vasculitides in Severa Alpha-1 antitrypsin Deficiency", Mazodier, P., et.al, QJM, 1996, 89:599-611.

"Recent Pulmonary Observations in Alpha-1 Antitrypsin Deficiency, Primary Biliary Cirrhosis, Chronic Hepatitis C, and Other Hepatic Problems", Krowka, M., CLINICS IN CHEST MEDICINE, 1996; 17/1: 67-82.

"Mechanisms of Relief of Exertional Breathlessness Following Unilateral Bullectomy and Lung Volume Reduction Surgery in Emphysema", O'Donnell, D., et.al., CHEST, 1996; 110: 18-27.

"Pulmonary Transplantation", Davis Jr., R. and Pasque, M., ANNALS OF SURGERY, 1995; 221/1: 14-28.

"The Other Emphysema", Brandly, S., J FOR RESPIR CARE PRAC, Feb.-March, 1995, pp. 103-110.

"Pathophysiology and Treatment of Alpha-1 Antitrypsin Deficiency", MacDonald,  J. and Johnson, C., AM J HEALTH-SYS PHAR, 1995; 52: 481-9.

"Clinical Manifestations of Alpha-1 Antitrypsin Deficiency", Perlmutter, D., GASTROENTEROLOGY CLINICS OF NORTH AMERICA, 1995; 24/1: 27-43.

"Pathophysiology and Treatment of Alpha-1 Antitripsin Deficiency", MacDonald, J and Johnson C, AM J HEALTH-SYST PHARM, March 1995, Vol. 52, pp. 481-489.

"The Proteinase-Antiproteinase Balance in Alpha-1 Proteinase Inhibitor-Deficient Lung Transplant Recipients", King M., et. al., AM J RESPIR CRIT CARE MED, 1994, Vol. 149, pp. 966-971.

"Replacement Therapy for Hereditary Alpha 1-Antitrypsin Deficiency", Barker A., et. al., CHEST, May 1994, pp 1406-1410.

"Strong Link Between Between the Alpha-1 Antitrypsin PiZ allele and Wegener's Granulomatosis", Elzouki, AN, et.al., J INTERNAL MED, 1994, 236:543-548.

"Clinical Features and Molecular Characteristics of Alpha-1 Antitrypsin Deficiency," Blank, C. and Brantly, M, ANNALS OF ALLERGY, 1994; 72: 105-21.

A Lag in Intracellular Degradation of Mutant Alpha-1 Antitrypsin Correlates with the Liver Disease Phenotype in Homozygous PiZZ Alpha-1 Antitrypsin Deficiency, Y Wu, I Whitman, E Molmenti, K Moore, P Hippenmeyer, and DH Perlmutter, Proc. Natl. Acad. Sci. USA.  1994 September 13; 91(19): 9014-9018

"Alpha-1 Proteinase Inhibitor and Pulmonary Haemorrhage in Systemic Vasculitis", O'Donoghue, DJ, et.al., 1993, ADV EXP MED BIOL, 336:331-335.

"Alpha-1 Antitrypsin Augmentation Therapy for Chronic Obstructive Lung Disorders", Crystal, R., DRUGS OF THE FUTURE, 1992, 17(5), pp 387-393.

"Alpha-1 Antitrypsin Deficiency and Liver Disease", Birrer P, et.al, J INHER METAB DIS, Dic. 1991; 14: 512-25.

"Use of Highly Purified Alpha-1 Antitrypsin Standard to Establish Ranges for Common Normal and Deficient Alpha-1 Antitrypsin Phenotypes", Brantly, M, et al, CHEST 1991; 100: 703-08.

"Alpha-1 Antitrypsin Deficiency: Lessons Learned from the Bedside to the Gene and Back Again", Eriksson, S., CHEST, 1989; 95/1: 181-89.

"The Alpha-1 Antitrypsin Gene and Its Mutations:  Clinical Consequences and Strategies", Crystal, R., et. al., CHEST, Jan. 1989, pp 196.208.

"Replacement Therapy for Alpha-1 Antitrypsin Deficiency Associated with Emphysema", Wewers, M., et. al., N ENGLAND J OF MED, April 1987, Vol. 316, No. 17, pp 1055-1062.

"Severe Deficiency of Alpha-1 Antitrypsin Deficiency Associated with Cutaneous Vasculitis, Rapidly Progressive Glomerulonephritis, and Colitis", Lewis, M et.al., 1985, AM J MED, 79:489-494.

"Deficiencia de Alfa-1 Antitripsina en la Paniculitis de Weber-Christian", Olmos L. Superby A, Lueiro M, et al, ACTAS DERMATOSIFILOGR, 1981, Vol. 72, pp 371-376.

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